Effect of adjuvant perioperative desmopressin in locally advanced canine mammary carcinoma and its relation to histologic grade

HERMO GA; TURIC E; ANGELICO D; SCURSONI AM; GOMEZ DE; GOBELLO C; ALONSO DF

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION

AMER ANIMAL HOSPITAL ASSOC

Año: 2011 vol. 47 p. 21 - 27

0587-2871

Desmopressin (DDAVP) is a vasopressin peptide analog with hemostatic properties that has been successfully used during surgery in patients with bleeding disorders. Recently published experimental and clinical data indicate that perioperative administration of DDAVP can minimize spread and survival of residual mammary cancer cells. The central aim of this study was to explore the effect of perioperative DDAVP and its relation to histologic grade in bitches with locally advanced mammary carcinoma. Of the 32 dogs initially recruited, 28 intact bitches with mammary carcinoma tumors stage III or IV were ultimately included. These dogs were randomized to receive DDAVP at intravenous doses of 1 μg/kg (n=18) or saline solution as placebo (n=10). En bloc mastectomy of the affected gland(s) was performed. Tumor malignancy was graded by the method of Elston and Ellis into well-differentiated (grade 1), moderately differentiated (grade 2), or poorly differentiated (grade 3). DDAVP therapy significantly prolonged the disease-free survival (P