MADRID Rossana Elena
congresos y reuniones científicas
Effect of sintered time of CaTiO3-CaCO3 in osteoblastic response of KUSA/A1 cells
RODRIGUEZ, ANDREA PAOLA; SÁNCHEZ, MARÍA ALEJANDRA; TSUJIGIWA HIDETSUGU ; INOUE MIHO ; FELICE, BETIANA; MADRID, ROSSANA; HITOSHI NAGATSUKA; FELICE, CARMELO
Paraná, Entre Ríos
Congreso; VI Latin American Conference on Biomedical Engineering CLAIB 2014; 2014
Soc. Arg. de Bioingeniería - CORAL
In recent years, calcium titanate (CaTiO3) and carbon-containing materials have gained much attention in a number of biomedical material researches. To maximize the advantages of both materials, we developed a novel alkoxide method to get ??calcium titanate with calcium carbonate?? (CaTiO3?CaCO3). Thus, our previous result indicated that calcium carbonate could play a key role in the cell response of CaTiO3 material. In the present study we evaluated the effect of sintering time of CaTiO3-CaCO3 in osteoblastic response of KUSA/A1 cells. We examined the material characterization as well as cellular proliferation and mineralization of KUSA/A1 cells cultured with the materials. The results showed that CaT-iO3?CaCO3 material sintered during 30 min, has better influ-ence on the bone marrow stromal cells for their proliferation and mineralization compared to CaTiO3-CaCO3 sintered at 2 and 10 h. These results suggest that sintering time could be directly related to the amount of carbon within CaCO3 being crucial in cell response. In conclusion, our preliminary find-ings indicate that CaTiO3?CaCO3 could play a more dominant and favorable effect on cell response when sintered for 30 minutes.