SENSOR SUBSTRATE FUNCTIONALIZATION FOR BIOSENSING APPLICATIONS

RICARDO M TRUJILLO; ANNA CATTANI-SCHOLZ; ACHYUT BORA; ANSHUMA PATAK; ROSSANA MADRID ; MARC TORNOW

Mar del Plata

Congreso; XVIII Congreso Argentino de Bioingeniería y VII Jornadas de Ingeniería Clínica, SABI 2011 junto con 2º Taller de Órganos Artificiales, Biomateriales e Ingeniería de Tejidos, OBI 2011; 2011

Soc. Arg. de Bioingeniería

Abstract..The main disadvantage of the present sensing methods is that samples must be labeled previous the measurements. In some cases, to obtain a reliable result, it is necessary to use considerable amount of analyte, or it is not possible to label it, making difficult to carry out these measurements. This paper describes the possibility of label-free biosensing based on crystalline silicon functionalized with organic molecules. This work started with the improvement of the p type silicon substrate by doping its back side with Boron. Several techniques were used to prepare the semiconductor, among them we find optic lithography, oxidation, doping and metallization. In order to get a response, it is necessary to prepare the sensor´s surface with a special oxidation technique that allows uncontaminated ultra-thin layers. Very good ohmic contact between sample and electrode is also needed. For this reason, extra Boron dopands were used in addition of the metal evaporated to create the contact.