Isoespintanol Isolated from Oxandra cf. xylopioides (Annonaceae) Leaves Ameliorates Pancreatic Dysfunction and Improves Insulin Sensitivity in a Murine Model of Fructose-Induced Prediabetes

FARROMEQUE VÁSQUEZ S; GONZÁLEZ ARBELÁES L; ROJANO B; SCHINELLA G; MAIZTEGUI B; FRANCINI F

Plants

Multidisciplinary Digital Publishing Institute

Año: 2025 vol. 14

2223-7747

Fructose rich diet triggers in rats, endocrine-metabolic disturbances like those present in human prediabetes. We evaluated the protective effect of isoespintanol, a monoterpene isolated from Oxandra cf. xylopioides (Annonaceae), on pancreatic islet. Animals were maintained for 21 days with a standard commercial diet and tap water (C), plus 10% fructose (F), or F plus isoespintanol (I; 10 mg/kg, i.p.). Glycemia, triglyceridemia, total-cholesterol, HDL-cholesterol, insulin-resistance index (IRX), and glucose tolerance test were determined. Glucose-stimulated insulin secretion (GSIS) and gene expression of insulin signalling mediators (insulin receptor -IR-, IRS1/2, PI3K), oxidative stress (SOD-2, GPx, GSR, 3´-nitrotyrosine), inflammation (TNF-α, IL-1β, PAI-1), mito-chondrial function (Bcl-2, mtTFA), and apoptosis markers were evaluated in pancreatic islets. F group increased triglyceridemia, non-HDL-cholesterol and IRX; decreased HDL-cholesterol, and impaired glucose tolerance; alterations reversed by isoespintanol administration (p