INVESTIGADORES
MINDLIN Bernardo Gabriel
artículos
Título:
Dynamical model of birdsong maintenance and control
Autor/es:
H. ABARBANEL; S.TALATHI; G. B. MINDLIN; M. RABINOVICH; L. GIBB
Revista:
PHYSICAL REVIEW E - STATISTICAL PHYSICS, PLASMAS, FLUIDS AND RELATED INTERDISCIPLINARY TOPICS
Editorial:
APS
Referencias:
Año: 2004 p. 1 - 16
ISSN:
1063-651X
Resumen:
The neuroethology of song learning, production, and maintenance in songbirds presents interesting similaritiesto human speech. We have developed a biophysical model of the manner in which song could be maintainedin adult songbirds. This model may inform us about the human counterpart to these processes. Insongbirds, signals generated in nucleus High Vocal center (HVc) follow a direct route along a premotorpathway to the robust nucleus of the archistriatum (RA) as well as an indirect route to RA through the anteriorforebrain pathway (AFP): the neurons of RA are innervated from both sources. HVc expresses very sparsebursts of spikes having interspike intervals of about 2 ms. The expressions of these bursts arrive at the RA witha time difference DT<50±10 ms between the two pathways. The observed combination of AMPA and NMDAreceptors at RA projection neurons suggests that long-term potentiation and long-term depression can both beinduced by spike timing plasticity through the pairing of the HVc and AFP signals. We present a dynamicalmodel that stabilizes this synaptic plasticity through a feedback from the RA to the AFP using known connections.The stabilization occurs dynamically and is absent when the RA!AFP connection is removed. Thisrequires a dynamical selection of DT. The model does this, and DT lies within the observed range. Our modelrepresents an illustration of a functional consequence of activity-dependent plasticity directly connected withneuroethological observations. Within the model the parameters of the AFP, and thus the magnitude of DT, canalso be tuned to an unstable regime. This means that destabilization might be induced by neuromodulation ofthe AFP