Editorial: Advances in Liver Inflammation and Fibrosis Due to Infectious Diseases

OLIVEIRA, SERGIO C.; DELPINO, M. VICTORIA; GIAMBARTOLOMEI, GUILLERMO HERNÁN; QUARLERI, JORGE; SPLITTER, GARY

Frontiers in Immunology

Frontiers Media S.A.

Año: 2020 vol. 11

In this Research Topic, a series of articles provide new insights about the current view of liverpathology, inflammation and fibrosis, with original articles about the role of myeloid suppressorcells in fulminant hepatitis, inflammasome activation in brucellosis, new insights in preventingNALDF progression, and the role of NLRP6 in granuloma formation and liver disease associatedwith schistosomiasis.This Research Topic also features three review articles regarding the role of glucocorticoids intherapy of liver failure, the interaction of liver and immune cells in brucellosis, the role of T cellsin hepatic schistosomiasis, as well as the role of beneficial bacterial in liver disease progression.Also included is a perspective article with proposed mechanisms of interaction between humanimmunodeficiency virus (HIV) and Kupffer cells.The original research articles included in this Research Topic were performed involving both invitro, and in vivo experiments in the murine model. Such model has acquired particular relevanceduring the study of non-invasive biomarkers able to assess fibrosis in patients with chronicliver disease.