INVESTIGADORES
GIAMBARTOLOMEI Guillermo Hernan
artículos
Título:
Immune Mediators of Pathology in Neurobrucellosis: From Blood to Central Nervous System
Autor/es:
RODRÍGUEZ AM, DELPINO MV, MIRAGLIA MC, GIAMBARTOLOMEI GH
Revista:
NEUROSCIENCE
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2019
ISSN:
0306-4522
Resumen:
Neurobrucellosis,which is the most morbid form of brucellosis disease, presents with inflammatorysigns and symptoms. Recent experimental evidence clearly indicates thatderegulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the centralnervous system (CNS) in which secretion of pro-inflammatory mediators lead todestabilization of the glial structure, the damage of the blood-brain barrier (BBB)and neuronal demise. This review of Brucellainteractions with cells of the CNS and the BBB is intended to present recentimmunological findings that can explain, at least in part, the basis for theinflammatory pathogenesis of the nervous system that takes place upon Brucella infection.
