INVESTIGADORES
GIAMBARTOLOMEI Guillermo Hernan
artículos
Título:
Adrenal steroids modulate the immune response during B. abortus infection by a mechanism that depends on the regulation of cytokine production
Autor/es:
M. V. GENTILINI, LIS VELÁSQUEZ, PAULA BARRIONUEVO, P. CONSTANZA ARRIOLA BENITEZ, GUILLERMO GIAMBARTOLOMEI, AND M. VICTORIA DELPINO
Revista:
INFECTION AND IMMUNITY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Lugar: Washington; Año: 2015 p. 1973 - 1982
ISSN:
0019-9567
Resumen:
Human brucellosis is a protean disease with a diversity of clinical signs and symptoms resulting from infection with Brucella species. Recent reports suggest a cross-regulation between adrenal steroids (cortisol and dehydroepianroesterone, DHEA) and the immune system. Monocytes and macrophages are the main replication niche for Brucella. Therefore, we investigated the role of adrenal hormones on the modulation of immune response of macrophages in B. abortus infection. Cortisol treatment during B. abortus infection significantly inhibits cytokine, chemokine and MMP-9 secretion; in contrast, DHEA treatment had no effect. However, DHEA treatment increases the expression of coestimulatory molecules (CD40, CD86), the adhesion molecule CD54 and MHC-I and MHC-II expression in the surface of B. abortus infected monocytes. It is known that B. abortus infection inhibit MHC-I and MHC-II expression induced by IFN-γ treatment. DHEAreverses B. abortus down modulation of the MHC-I and II expression induced by IFN-γ. Taken together our date indicate that DHEA immune intervention may positively affect monocyte function since we observed an induction of a pro-inflammatory milieu, increment on the MHC-I and MHC?II molecules and coestimulatory molecules and adhesion enhancement.