Dependent- and independent-endotelium vasodilation in children with low birth weight and its relationship with urinary nitrites

PERAL DE BRUNO, M.; LOPEZ ZIGARAN, S.; JOO TURONI, C.; CHAHLA, R.; CHAILA, M.; SALINAS, J.; SEU, F.; MAMANI, I.; OLASO, G.; DE BOECK, J.; CASELLA, S.; BRUNO, M.; BAZAN DE CASELLA, M.

Puerto Varas

Congreso; XXV Congreso de la Sociedad Latinoamericana de Endocrinología Pediátrica; 2015

Sociedad Latinoamericana de Endocrinología Pediátrica

Objective: To study, in children with low birth weight (LBW), urinary nitrites, and its relation with endothelial dependent (ED)- and independent (EID)-endothelium vasodilation. Methods: Children (4?6 years) with LBW (n = 20) or not (control: n = 11) were studied. Waist circumference, height, weight, blood pressure (BP), glucose, insulin, HOMA-IR, lipid profile and C reactive protein (uCRP) were determined. ED (reactive hyperaemia), EID (relaxation by topic nitroglycerin) and arterial stiffness (AS) were measured by pulse wave plethysmography. Nitric oxide bioavailability was determinate by urinary nitrites.Results: LBW showed decreased ED (control: 98 ± 33 vs. LBW: 43 ± 9%; p < 0.04) with similar EID and AS respect to controls. Urinary nitrites and uCRP were significantly increased in LBW. No differences between anthropometric parameters and others cardiometabolic risk markers were found. A positive correlation between urinary nitrites and uCRP was found only in LBW (Pearson r = 0.78; 95% CI = 0.52?0.91; p < 0.001). Conclusions: The alterations in ED with similar values of EID and AS indicate an earlier endothelial damage in children with LBW, which is accompanied by a proinflamatory state (uCRP increased). The fact that LBW presented an increased urinary nitrite levels and its correlation with uCRP indicates an compensatory activation of systemic nitric oxide bioavailability at this early stage of life.