INVESTIGADORES
PERAL Maria De Los Angeles
congresos y reuniones científicas
Título:
Impact of low birth weight in vascular function and autonomic regulation of blood pressure
Autor/es:
PERAL DE BRUNO, M.; JOO TURONI, C.; CHAHLA, R.; CHAILA, M.; LLICAS, S.; NAVARRO, A.; ÁLVAREZ SOLLASI, C.; DUPUY, M.; LOPEZ ZIGARAN, S.; BAZÁN DE CASELLA, M.
Lugar:
Puerto Varas
Reunión:
Congreso; XXV Congreso de la Sociedad Latinoamericana de Endocrinología Pediátrica; 2015
Institución organizadora:
Sociedad Latinoamericana de Endocrinología Pediátrica
Resumen:
Objective: Assess the impact of low birth weight (LBW) on heart rate variability (HRV), endothelial function (EF), arterial stiffness (AS) and C-reactive protein (CRP) on vascular function in children and to determine its relationship with early markers of cardiometabolic risk.Methods: Children aged 4 to 6 years with LBW (n = 51) or not (control: n = 31) were studied. Waist circumference, height, weight, blood pressure (BP), glucose, insulin, HOMA index, Quicky, lipid profile and CRP were determined. EF was measured by pulse wave plethysmography evaluating flow-mediated vasodilation. AS was determined by morphology of digital pulse wave. Variability of heart rate (HR) beat to beat (VFC: standard deviation of the interval between beats); spontaneous variability of heart rate (percentage of consecutive beats that differ more than 50%: pNN50) and the product of the maximum HR and SBP (MHRxSBP) were measured.Results: Although waist circumference, height, weight, systolic BP (SBP) and diastolic BP (DBP) were within the 90th percentile in LBW and control; LBW had higher SBP (p < 0.05) and HR (p < 0.01). Furthermore, insulin, HOMA and Quicky were within normal limits; but in LBW insulin and HOMA were increased and Quicky was decreased. LBW presented increased CRP (control: 0.7 ± 0.2 mg/l vs. LBW: 2.0 ± 0.5; p < 0.029). The EF was decreased in LBW (control: 69 ± 11 vs. LBW: 38 ± 6%; p < 0.01) without changes in AS. Only LBW presented a positive correlation between SBP and DBP and negative correlation between EF and AS. VFC and pNN50 was similar in both groups. MHRxSBP was higher in LBW (control: 9,463 ± 629 vs. LBW: 10,923 ± 409 beat (mm Hg)/ min; p < 0.01). Only in LBW a positive correlation between pNN50 with MHRxSBP and a negative correlation between EF with CRP and CRP with HDL cholesterol was found.Conclusions: Although LBW have anthropometric and biochemical parameters and BP within normal limits, they have SBP increased. The decreased EF supports the hypothesis that these alterations involve endothelium-dependent vasodilator tone more than AS. Endothelial dysfunction would be early associate with a proinflammatory state (increased CRP). Alterations of autonomic control (increase of MHRxSBP and its relationship with pNN50) would be added.