Evaluation of early markers of risk for metabolic syndrome and vascular function in children with intrauterine growth restriction.

CHAILA ZULEMA; M. PERAL DE BRUNO; CLAUDIO JOO TURONI; CHALHA ROSSANA; GRAIFF OLGA; NEGRETE ALEJANDRO; BRUNO MARIA ELISA; BAZAN DE CASELLA CRISTINA

Milan

Congreso; 52st Annual Meeting of the European Society for Paediatric Endocrinology; 2013

European Society for Paediatric Endocrinology

Background: Intrauterine growth restriction(IUGR) is considered a cardiovascular risk factor, this would result in the appearance in Metabolic Syndrome (MS).Objective: To study the relationship between the early markers of risk of MS and assess endotelila function:EF in children with a history of IUGR.Methods: A cross-sectional study was performed. Population:120 children born with low birth weight (2006-2009) from Maternity (84 were IUGR). Signed informed consent from parents was required. Anthropometric variables and biochemical parameters were: body mass index:BMI, waist circumference:WC, glucose:G, insulin:I, HOMA and QUICKI:QI, lipid profile and IGF-1. EF was assessed by plethysmography digital pulse wave before and after of reactive hyperemia maneuver. Pearson correlation coefficient was used. Results: Birth weight and weeks and gestational age:GA were 2297.0±24 g and 37±0.2 respectively. The mean values were: G 78±1 mg/dl, I 8.25±0.7 uUI/ml, HOMA 1.6±0.1, IQ: 0.36±0.03, HDL 45±1 mg/dl, TG:86±5 mg/dl,TG/HDL 2.1±0.2 and IGF-1 165±11 ng/ml and PCR 2.0±0.5 mg/l. The presence of MS was 14%.Both BMI and WC were correlated with HOMA (0.35 p=0.003 and 0.24 p=0.03) and IQ (-0.27 p=0.03 and -0.28 p=0.01). The diastolic blood pressure (DBP) was correlated with WC (0.29 p=0.007) and BMI with systolic blood pressure (SBP p=0.02). HOMA, IQ and HDL correlated with TG (p=0.003, p=0.02 and p=0.001 respectively). IGF-1 correlated with BMI (p=0.034), WC (p=0.001), HOMA (0.22 p=0.049), IQ (-0.35 p=0.001). A positive correlation between SBP and DBP (p=0.001) was found, accompanied by a differential pressure increased (p=0.001). EF were correlated with both GA (0.55 p=0.01) and DBP (p=0,04). Conclusions: Children with IUGR were significantly associated with early markers of risk of MS.The positive correlations observed between anthropometric variables with biochemical parameters and endothelial dysfunction, suggesting that IUGR would be potential carriers MS.