INVESTIGADORES
PERAL Maria De Los Angeles
artículos
Título:
ANTIOXIDANT TREATMENT REVERTS INCREASED ARTERIAL BASAL TONE AND OXIDATIVE STRESS IN NEPHRECTOMIZED (5/6) HYPERTENSIVE RATS
Autor/es:
MARAÑÓN, RODRIGO; JOO TURONI C; KARBINER SOFIA; SALAS NICOLÁS,; PERAL DE BRUNO MARIA
Revista:
International Journal of Hypertension
Editorial:
Hindawi Publishing Corporation
Referencias:
Año: 2013 vol. 5 p. 1 - 8
ISSN:
2090-0392
Resumen:
ABSTRACT Non-ischemic 5/6 nephrectomized rat (NefR) is a model of chronic kidney disease. However, little is known about vascular dysfunction and its relation with hypertension in NefR. Aims: To evaluate possible alterations of endothelial function, NO-bioability and basal tone in aorta from NefR and the role of oxidative stress. Sprague Dawley rats were divided in: sham rats (SR), NefR and NefR treated with tempol (NefR-T). Mean arterial pressure (MAP) and renal function was determined. In isolated aortic rings was measured: 1-Endothelial function, 2-Basal tone, 3-NO levels, 4-Membrane potential (MP) and 5-Oxidative stress. NefR increased MAP (SR: 119±4 mmHg; n=7; NefR 169±6; n=8; p