INVESTIGADORES
PERAL Maria De Los Angeles
artículos
Título:
CROSS TALK BETWEEN ALPHA 1 ADRENERGIC AND ANGIOTENSIN II RECEPTORS IN RABBIT AORTA: ROLE OF ENDOTHELIUM.
Autor/es:
JEREZ, SUSANA; MARIA DE LOS ANGELES PERAL; COVIELLO, A
Revista:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Editorial:
Lippincott Williams & Wilkins
Referencias:
Lugar: Estados Unidos; Año: 2004 vol. 43 p. 402 - 409
ISSN:
0160-2446
Resumen:
Abstract: Interaction between the renin-angiotensin system and the
sympathetic nervous system has been proposed to be like a physiological
regulation mechanism. The present work was designed to
study the cross talk between angiotensin II and adrenergic receptors
on the smooth muscle contractile response and the endothelium influence
in this phenomenon. Homologous and endothelium independent
desensitization of angiotensin II-contractile response was observed.
Treatment with noradrenaline between two cumulative doses response
curves (CDRC) to angiotensin II caused a rightward shift of
the second CDRC in unrubbed arteries and increased the maximal
response in rubbed arteries. Prazosin blocked these effects. No homologous
desensitization of noradrenaline contractile response was
found. Treatment with angiotensin II between two CDRC to noradrenaline
caused a loss of affinity in the second CDRC in unrubbed
arteries. Losartan was able to avoid this phenomenon. Maximal response
was enhanced both in arteries with and without endothelium
treated or not with angiotensin II. Results demonstrate homologous
and endothelium-independent desensitization of the contractile response
to angiotensin II but not to noradrenaline. In addition, heterologous
and endothelium-dependent desensitization induced by noradrenaline
and angiotensin II on the contractile response to each other
was found. Furthermore, results provided the first evidence that there
is an endothelium-dependent cross talk between 1-adrenergic and
angiotensin II receptors in smooth muscle of rabbit aorta.Interaction between the renin-angiotensin system and the
sympathetic nervous system has been proposed to be like a physiological
regulation mechanism. The present work was designed to
study the cross talk between angiotensin II and adrenergic receptors
on the smooth muscle contractile response and the endothelium influence
in this phenomenon. Homologous and endothelium independent
desensitization of angiotensin II-contractile response was observed.
Treatment with noradrenaline between two cumulative doses response
curves (CDRC) to angiotensin II caused a rightward shift of
the second CDRC in unrubbed arteries and increased the maximal
response in rubbed arteries. Prazosin blocked these effects. No homologous
desensitization of noradrenaline contractile response was
found. Treatment with angiotensin II between two CDRC to noradrenaline
caused a loss of affinity in the second CDRC in unrubbed
arteries. Losartan was able to avoid this phenomenon. Maximal response
was enhanced both in arteries with and without endothelium
treated or not with angiotensin II. Results demonstrate homologous
and endothelium-independent desensitization of the contractile response
to angiotensin II but not to noradrenaline. In addition, heterologous
and endothelium-dependent desensitization induced by noradrenaline
and angiotensin II on the contractile response to each other
was found. Furthermore, results provided the first evidence that there
is an endothelium-dependent cross talk between 1-adrenergic and
angiotensin II receptors in smooth muscle of rabbit aorta.1-adrenergic and
angiotensin II receptors in smooth muscle of rabbit aorta.
Keys Words: adrenergic receptors, angiotensin II, cross talk, endothelium
(J Cardiovasc Pharmacol 2004;43:4024adrenergic receptors, angiotensin II, cross talk, endothelium
(J Cardiovasc Pharmacol 2004;43:4024J Cardiovasc Pharmacol 2004;43:4024