ANGIOTENSIN CONVERTING ENZIME INHIBITOR POTENTIATED THE VASORELAXANT RESPONSE OF ATRIAL NATRIURETIC PEPTIDE IN TOAD AORTIC RINGS

MARIA DE LOS ANGELES PERAL; COVIELLO, ALFREDO

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART B, BIOCHEMISTRY & MOLECULAR BIOLOGY.

ELSEVIER

Lugar: Inglatera; Año: 1990 vol. 95 p. 327 - 332

1096-4959

1. The vasorelaxant effect of synthetic atrial natriuretic peptide (ANP) on the vascular response to angiotensin II (A II) and norepinephrine (NE) in aortic rings from Bufo arenarum toad was studied. 2. Pretreatment with ANP partially inhibited the vascular response to A II and NE. 3. Angiotensin converting enzyme inhibitor (ACEI) treatment partially inhibited the contractile response of angiotensin I (A I) and did not affect the A II response. 4. The inhibitory effect of ANP on vascular response to A II and NE were potentiated by pretreatment with ACEI. 5. Results suggest that the angiotensin converting enzyme present in the vascular wall from Bufo arenarum toad may be involved in the metabolism of ANP. PMID: 1977559 [PubMed - indexed for MEDLINE]