Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina

CHAHLA ROSSANA; LUIS RUIZ MEDINA; MIGUEL FERRE; MARIO RAYA; NATALIA HERRRERA; EUGENIA S. ORTEGA; DANIEL G. GOROSO; MARIA DE LOS ANGELES PERAL

Journal of Infectious Diseases & Therapy

Ed. ORGDesase

Año: 2022

Purpose: The objective of this work is to make an observational study of the usage in moderate or severe state COVID-19 patients of a new therapeutic commercial product obtained after immunization of horses: CoviFab® ELEA F(ab´)2 fragmented equine immunoglobulins anti SARS-CoV2. Methods: Participant centers depend on the Public Health System of Tucumán, Argentina were recruitment. Subjects were assigned to the Moderate Patient Group (MPG) and the Severe Patient Group (SPG), classified according to WHO criteria. In total, n=84 were enrolled for this study. The subjects were divided into MPG and SPG. All participants were evaluated by physical examination and COVID-19 infection was diagnosed with positive RT-PCR. Each subject received two doses of 0.16 ml/kg, according to the subject´s body weight. A generalized linear model with binomial distribution was adjusted for the number of symptoms. Data was analysed using proportion, bivariate and logistic regression. P-value was consideredsignificant at the p