INVESTIGADORES
MIRANDA Silvia Esther
congresos y reuniones científicas
Título:
Effects of acoustic stress on glucose homeostasis
Autor/es:
MIRANDA S; SOSA G; MAMANI AE; TAVERNA M
Lugar:
Mar del Plata, Buenos Aires
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017
Institución organizadora:
Sociedad Argentina de Investsigaciones Clínicas
Resumen:
Inflammatory bowel diseases (IBD) are frequently associated with diabetes mellitus (DM2). Our previous results showed that acoustic stress (AS) induces long term severe intestinal inflammation in the mouse. In the present study, our aim was to investigate whether AS affects glucose homeostasis. Two-month old CBA/J male mice were subjected to two oral glucose tolerance tests (OGTT) determining glucose levels at 0-30-60-120 min. Then, mice were randomized into AS (n=7) and control (C) (n=6) groups. AS mice were exposed to noise (300Hz-70dB) during 24hs with food and water ad libitum. Three AS protocols were assessed: I- 3 month old mice were exposed weekly to 1 AS during 5 weeks, II- At 6 months old, the same animals received weekly 2 AS during 5 weeks and III- Mice were re-exposed to AS twice a week for 5 weeks at 13 mo old. After each AS protocol, two OGTT were assessed. All animals were weighted throughout the whole experiment. Finally, animals were exanguinated for insulinemia and glucagonemia determinations and killed. Results showed: I- AS increased blood glucose and the OGTT area under curve (AUC) by 20% (p