INVESTIGADORES
OTERO-LOSADA Matilde Estela
congresos y reuniones científicas
Título:
CARAMEL-CONTAINING SOFT DRINKS IMPAIR PANCREATIC FUNCTION AND INSULAR MORPHOLOGY IN RATS
Autor/es:
OTERO-LOSADA M; CAO G; GONZALEZ J; MULLER A; OTTAVIANO G; LILLIG CH.; CAPANI F.; AMBROSIO G; MILEI J.
Lugar:
Milán
Reunión:
Congreso; 25th European Meeting on Hypertension and Cardiovascular Protection; 2015
Institución organizadora:
European Society of Hypertension. International Society of Hypertension
Resumen:
Objective:This study was carried out in order to examine the impact of long-term consumption of caramel-containing soft drinks (cola beverages) on glycemic balance and endocrine pancreas function and morphology in rats.Design and method:Sixty-fourWistar rats drank water (W), regular cola beverage (C, sucrose sweetened) for 6 months (treatment). Euthanasia was performed in 50 % of the animals in each group. The remaining animals carried on drinking water for the next 6 months until euthanasia administration (wash-out). Insulinemia,plasma biochemistry andpancreas morphometry and immunohistochemistry evaluations were performed. Insulin resistance (HOMA-IR) was computed.Results:Hyperglycemia (16%, p
