INVESTIGADORES
OTERO-LOSADA Matilde Estela
congresos y reuniones científicas
Título:
Effect of moderate exercise on glomerulosclerosis and hypertriglyceridemia after regular cola beverage
Autor/es:
OTERO-LOSADA M.; CAO G.; GONZALEZ J; MULLER A; AMBROSIO G.; MILEI J.
Lugar:
Athens
Reunión:
Congreso; EUROPEAN SOCIETY OF HYPERTENSION (ESH) AND INTERNATIONAL SOCIETY OF HYPERTENSION (ISH) JOINT MEETING.; 2014
Institución organizadora:
Eur Society of Hypertension
Resumen:
Abstract
Purpose. To evaluate 1) the
effect of cola drinks (CD) consumption on lipid profile and kidney damage in
rats and 2) a possible beneficial role of aerobic exercise. High consumption of cola drinks (CD) increases the risk
of obesity, diabetes, metabolic syndrome and chronic kidney disease. Chronic
intake of sugar-sweetened beverages appears to be linked to proteinuria and
associated with poor physical activity, hyperlipemia and renal damage.
Methods. Forty-eight adult male Wistar-Kyoto rats were randomized to treatment groups.
Runners (aerobic exercise): WR (drinking water), CR (drinking sucrose-sweet
cola). Sedentary: WS and CR analogously. Lipid profile, glycemia, atherogenic
index of plasma (AIP) and systolic blood pressure (SBP) were determined at
different times. Euthanasia was practiced 6 months after the beginning of the
study. Kidney histopathological score was obtained using a semiquantitative
scale. Glomerular size and glomerulosclerosis were estimated by point-counting.
Results. Histopathological score in sedentary rats was higher than in runner
rats regardless drink treatment. Glomerulosclerosis increased only in CS. Chronic
cola consumption resulted in food intake decrease and increased fluid intake,
plasma triglycerides, AIP and glomerulosclerosis
Conclusions. These findings suggest a negative effect of chronic
sucrose-sweet cola beverage drinking on lipid metabolism and kidney structure,
pointing to a beneficial role of moderate exercise. Hypertriglyceridemia might
be critical in boosting renal damage.