EFFECT OF MODERATE EXERCISE ON GLOMERULOSCLEROSIS AND HYPERTRIGLYCERIDEMIA AFTER REGULAR COLA BEVERAGE

CAO G.; OTERO-LOSADA M.; GONZALEZ JULIAN; MULLER A; AMBROSIO G; MILEI J.

Athens

Congreso; Eur Soc Hypertension Joint Meeting Internat Soc Hypertension 2014; 2014

Eur Society of Hypertension

Purpose. To evaluate 1) the effect of cola drinks (CD) consumption on lipid profile and kidney damage in rats and 2) a possible beneficial role of aerobic exercise. High consumption of cola drinks (CD)increases the risk of obesity, diabetes, metabolic syndrome and chronic kidney disease. Chronic intake of sugar-sweetened beverages appears to be linked to proteinuria and associated with poor physical activity, hyperlipemia and renal damage. Methods. Forty-eight adult male Wistar-Kyoto rats were randomized to treatment groups. Runners (aerobic exercise): WR (drinking water),CR (drinking sucrose-sweet cola). Sedentary: WS and CR analogously. Lipid profile, glycemia, atherogenic index of plasma (AIP) and systolic blood pressure (SBP) were determined at different times. Euthanasia was practiced 6 months after the beginning of the study. Kidney histopathological score was obtained using a semiquantitative scale. Glomerular size and glomerulosclerosis were estimated by point-counting. Results.Histopathological score in sedentary rats was higher than in runner rats regardless drink treatment. Glomerulosclerosis increased only in CS.Chronic cola consumption resulted in food intake decrease and increased fluid intake, plasma triglycerides, AIP and glomerulosclerosis. Conclusions. These findings suggest a negative effect of chronic sucrose-sweet cola beverage drinking on lipid metabolism and kidney structure, pointing to a beneficial role of moderate exercise. Hypertriglyceridemia might be critical in boosting renal damage.