IMMUNE SYSTEM LINKS PSORIASIS MEDIATED INFLAMMATION TO CARDIOVASCULAR ALTERATIONS VIA TRADITIONAL AND NON-TRADITIONAL CARDIOVASCULAR RISK FACTORS

KOLLIKER FRES R.; OTERO-LOSADA M.; KERSBERG E.; COSENTINO V.; CAPANI F.

Psoriasis

InTech Open

Lugar: Rijeka; Año: 2017; p. 91 - 119

DOI: 10.5772/intechopen.68559Medicine » "An Interdisciplinary Approach to Psoriasis", book edited by Anca Chiriac, ISBN 978-953-51-3252-3, Print ISBN 978-953-51-3251-6, Published: July 5, 2017 under CC BY 3.0 license. © The Author(s).////////////////////////////////////////////////////////////////////////////////Background. Important body of evidence, mostly epidemiologic, indicates that cutaneous psoriasis and psoriatic arthritis patients are at higher risk of developing cardiovascular disease. However, underlying mechanism remains not completely understood. Here we discuss the role of the immune system in the development of atherosclerosis and available data implicating the role of an enhanced immune mediated proinflammatory status in psoriasis and psoriatic arthritis diseases.Methods. We performed a Pubmed query covering publications within the last ten years and including epidemiological studies (prospective and retrospective), cross-sectional case-control studies and reviews. Articles were selected according critical associations using the terms arthritis, immune-mediated inflammatory diseases, and psoriasis as key fields. These were crossed and combined with atherogenesis, endothelial dysfunction, intima-media thickness, subclinical atherosclerosis, plaque, thrombosis, thrombus, fibrinolysis, coagulation, and reactive oxygen species, all closely related to cardiovascular diseases. Both types of disease selected terms were separately combined with both non-traditional (innate and adaptive pro- and anti-inflammatory immune molecules and cells) and traditional (metabolic related conditions and molecules) cardiovascular risk factors.Results and conclusions. Search results illustrated that immune-activated crossroads are the main contributors to proatherogenic inflammation in psoriasis and psoriatic arthritis disease. Cardiovascular risk factors are the result of the interplay between different proatherogenic mediators derived from metabolic, vascular and autoimmune joint and skin inflammation in target tissues. The effects of the immune system are mediated by traditional and non-traditional cardiovascular risk factors via an active crosstalk. Consistent with this point of view, psoriasis and psoriatic arthritis diseases offer an invaluable scenario to deepen our knowledge on atherosclerotic cardiovascular disease.