THE ANGIOTENSIN AFFAIR: HOW GREAT MINDS THINKING ALIKE CAME TO A HISTORICAL AGREEMENT

OTERO-LOSADA M; NOBILE MARIANA H; MILEI JOSÉ

Renin-Angiotensin System

Intech Open

Año: 2017;

In 1934, J. C. Fasciolo had to submit a thesis and Dr. Houssay suggested he investigateabout nephrogenic hypertension. E. Braun‐Menéndez showed interest in helping and Drs.L.F. Leloir and J.M. Muñoz from the Institute of Physiology joined them in their attemptto isolate and purify the pressor substance. In 1939, they extracted the substance ?hypertension?from the venous blood from the ischemic kidneys. They proposed an enzymesubstratereaction. They named hypertensinogen the substrate and hypertensinases theenzymes that break down the hypertension. Two months following the Argentine publication,the team in the United States, formed by I.H. Page and O.M. Helmer, published theirfindings, which were in agreement with those reported by the Argentine team. By 1940,they isolated angiotonin, the equivalent of hypertension, and called the renin substratehypertensinogen. In 1957, in the conference held in Ann Arbor, Braun‐Menéndez andPage agreed on a new nomenclature. As a result, the words angiotensinogen and angiotensinwere born from the combination of the names originally set by both teams. Thediscovery of the renin‐angiotensin system is an example that science should follow: Valuethe progress made by colleagues, collaborate side by side, and pursue the ultimate truth.