Oxidative Medicine in Brain Injury

OTERO-LOSADA, MATILDE; CAPANI, FRANCISCO

CURRENT PHARMACEUTICAL DESIGN.

BENTHAM SCIENCE PUBL LTD

Año: 2020 vol. 25 p. 4735 - 4736

1381-6128

Traumatic brain injury (TBI), a complex injury with a broad spectrum of symptoms and disabilities, not only pertains to adults but alsonewborns. Nearly one-third of the world population suffers from neurological diseases including Parkinson?s and Alzheimer?s diseases, multiplesclerosis, epilepsy, and spinal cord injury. Sometimes, deficits are seen in childhood and in others, they are delayed, arising in adolescenceor young adulthood. Understanding brain injury pathophysiology contributes to identifying new neuroprotective agents.. While oxidativestress affects brain tissue and function, the other way round is also true. Oxidative stress and its foregone vicious epigenetic regulationfollow traumatic brain injury and hemorrhagic stroke in the vascular neural network. Whether cause or effect, oxidative stress is a doubleedgedsword. It may help in fighting bacteria, but it may destroy the host too. This latent phase susceptible to an incidental and secondaryinjury brings about a therapeutic window and sets the grounds for neuroprotection. The aim of this special issue is bringing together the accruedresearch addressing the role of the reactive oxygen species (ROS) in the pathophysiology of brain injury and possible therapeuticstrategies.This special issue is focused on neuroprotective strategies for the brain, their possible pathways, and pharmacological analogs? use. Thetopics include:? New insights on oxidative damage and iron associated impairment in Traumatic Brain Injury. This chapter is focused on the hemorrhagecaused by trauma and the ongoing oxidative process generated by biochemical disturbances in brain tissue which increase thelevel of iron and reactive oxygen species. The relationship between oxidative damage and the traumatic brain injury is well-known, forthat reason, diminishing of the factors that potentiate the production of reactive oxygen species has promissory therapeutic uses. Ironchelators scavenge oxidative damage. The authors show an updated overview of the underlying mechanisms of oxidative damage in TBI,introducing the potential use of iron chelators as neuroprotective compounds [1, 2].? Copper and neurotoxicity in autism spectrum disorder. The authors discuss the role.....continues