INVESTIGADORES
OTERO-LOSADA Matilde Estela
artículos
Título:
Neuroprotection in Brain Hypoxia
Autor/es:
OTERO-LOSADA MATILDE; CAPANI, FRANCISCO
Revista:
Frontiers in Neuroscience
Editorial:
Lausanne : Frontiers Research Foundation
Referencias:
Lugar: Lausanne; Año: 2019
ISSN:
1662-4548
Resumen:
Despite there is compelling preclinical evidence from laboratory models of brain hypoxia suggesting potential neuroprotective strategies, only scattered data are available from clinical studies. In this regard, a few candidate neuroprotectants have been little studied based on their antioxidant, antiapoptotic, anti-excitotoxic, immunomodulatory, and neurotrophic effects.In parallel with clinical innovations, preclinical research initiatives are also identifying new animal models that more closely resemble the clinical course and pathology of neurodegenerative diseases.Clarifying the specific mission of the brain cells involved in the damage/repair system in the examined animal models is important to define new therapeutic targets. Moreover, this is so considering that after hypoxic damage, detrimental events like excitotoxicity, pro-apoptosis, pro-inflammatory reaction, and others intermingle with the repairing events in both time- and cellular-dependent fashion. Identifying more reliable post hypoxia brain markers is mandatory to design and develop potential therapeutic interventions over the follow-up time after the hypoxic episode, improving translational research from the experimental observations to the clinical application.Thus, a deeper understanding of the precise participation of neurons, glia, and endothelial cells by contrasting and comparing the outcome of studies using animal vs. cellular models might be expected to offer more clues for designing new therapeutic strategies to reduce the current gap among the experimental and the clinical data. One of the main issues should be to study the epigenetic mechanism of neuroprotective agents and their action on the genetic modification induced by hypoxia. Achieving this goal is presumed critical to obtain more conclusive results in patients that by now do not receive an appropriate therapy for mitigating the several diseases generated by brain hypoxia. Although a few ongoing studies are evaluating interesting approaches, future research is necessary to come to a novel mechanism of neuroprotection.Here we summarize the contributing articles to our Topic conveying the goals and aims of the pertaining research.