Patterns of necrosis and survival in myocardial infarction: natural history versus contemporary treatment

GASTÓN A RODRIGUEZ-GRANILLO; MATILDE OTERO-LOSADA; CARLOS FERNANDEZ-PEREIRA; JOSE MILEI

Revista Argentina de Cardioangiología intervencionista

CACI Colegio Argentino de Cardioangiólogos Intervencionistas

Lugar: Buenos Aires; Año: 2017 vol. 8 p. 179 - 182

2250-7531

We sought to compare patterns of ST-segment elevation myocardial infarction (STE-MI) before the introduction of reperfusion therapies, and with contemporaneous sta-te-of-the-art treatment of STEMI. Two cohorts of patients admitted for STEMI and without previous myocardial infarction constituted the study population. Group A (natural history) comprised a consecutive series of autopsies performed in patients dying of STEMI admitted between the years 1975 and 1977. Group B comprised a contemporary consecutive cohort of patients who underwent primary percuta-neous coronary intervention (PCI) for STEMI and were examined with delayed-en-hancement computed tomography immediately after completion of PCI. Demogra-phical characteristics overall did not differ between groups. All patients in group A showed evidence of necrosis, whereas only 14 (47 %) in group B showed evidence of irreversible myocardial damage. The measured infarcted mass was larger in the na-tural history group (27±14 % vs. 11±17 %; p