Trigeminal irritation induced by benzoic acid: a time-intensity report

OTERO-LOSADA, M.

Int. J. Psychophysics. Fechner Day

D. Kornbrot, R. Msetfi, S. MacRae (Eds.)

Lugar: St. Albans, Hertfordshire, UK; Año: 2006 p. 302 - 307

ABSTRACT Benzoic acid (BA) pungency was kinetically characterized. Psychophysical methodology was used by computerized record of pungency intensity across time. Benzoic acid (BA) pungency was kinetically characterized. Psychophysical methodology was used by computerized record of pungency intensity across time. Benzoic acid (BA) pungency was kinetically characterized. Psychophysical methodology was used by computerized record of pungency intensity across time. Benzoic acid (BA) pungency was kinetically characterized. Psychophysical methodology was used by computerized record of pungency intensity across time. Benzoic acid (BA) pungency was kinetically characterized. Psychophysical methodology was used by computerized record of pungency intensity across time. The main attribute of BA was pungency (3-36mM) on tongue. The seven kinetic parameters varied in a concentration-dependent manner (P<0.001), following different functions: a) linear: Imax =2.24±0.14 * C-3.06±2.58 (Maximum Intensity); R2=0.98; Timax =0.19±0.02 * C+6.87±0.47; R2= 0.92 (Time to achieve Imax,); V1 =0.68±0.03 * C+0.10±0.69 (Increase rate); R2=0.99; AUC=49.10±3.17 * C-230.78±59.66; R2= 0.98 (Area under curve); and b) power: T1/2=6.62±0.61* C0.39±0.03, R2=0.97 (Half Life); V2=1.07±0.11* C0.53±0.04, R2=0.96 (Decrease rate); Ttot=8.08±1.01* C0.43±0.04, R2=0.96 (Total Time). PCA showed high correlation among: a) Timax and Ttot; b) T1/2 and V2; c) Imax, and V1. Stimuli grouped into three clusters (mM): a). 3 and 6; b). 9, 12 and 18; c). 24 and 36. Prototypical BA prickling would be induced by 12-18 mM.