INVESTIGADORES
PONCE DAWSON Silvina Martha
congresos y reuniones científicas
Título:
The interplay of dynamics and geometry in intracellular Ca2+ signals
Autor/es:
PONCE DAWSON, SILVINA
Lugar:
Cuernavaca
Reunión:
Workshop; Dynamics of Regulatory Networks; 2013
Resumen:
Calcium signals are ubiquitous. Their versatility relies on the variety of distributions that the intracellular calcium concentration can display. The concentration of free calcium is very low in the cytosol. Calcium signals are the result of local calcium elevations that occur when individual channels allow the passage of the ions from the extracellular medium or intracellular stores. Calcium ions, in turn, act upon the channels affecting their open probability. Cells, on the other hand, have several mechanisms to lower the free cytosolic calcium concentration bringing it back to basal levels. Calcium signals are the result of the combined effects of all these mechanisms. The spatial distribution of the channels and the dynamics of the various calcium handling processes are then responsible for the final shape of the calcium signal. In this talk I will show examples on how these two aspects contribute to shape calcium signals and discuss ways on how to combine experiments and mathematical modeling to unveil the processes that underlie intracellular calcium signals.