Bone Marrow-Derived Cells and Peripheral Nerve Injury: Translational Implications for Pain and Regeneration Treatments

VANINA USACH; FLORENCIA CORONEL; MARIANA MALET; GONZALO PIÑERO; CANDELARIA LEIGUARDA; MAILIN CASADEI; MARCELO VILLAR; CLARA P. SETTON; PABLO R. BRUMOVSKY

Clinical Pharmacology and Translational Medicine

Applis Publisher

Lugar: Scottsdale; Año: 2018 vol. 2 p. 112 - 124

2572-7656

Traumatic injury of peripheral nerves is a serious concern for both patients and clinicians, and is commonly associated to neuropathic pain and complete or partial loss of functionality of the affected limb. Stem cell therapy has emerged as a promising tool to improve the outcome of patients with peripheral nerve injury, and an increasing number of pre-clinical and clinical studies are adding support towards their use in humans. In the present review, we will address specifically the participation of bone marrow stromal cells (BMSC;including a group of multipotent adult progenitor cells (MAP)) and bone marrow mononuclear cells (BMMC, a heterogeneous fraction that contains BMSC populations, among others), both of endogenous origin or exogenously transplanted, for the control of pain and the improvement of regeneration. We will describe the state-of-the-art knowledge on the cellular and molecularmechanisms involved in the action of BMSC and BMMC during traumatic injury of nerves. Finally, we will address the translational implications that may eventually lead to therapeutic options for humans.