VITAMIN-D TREATMENT DOES NOT IMPROVE PREGNANCY RATES IN PATIENTS UNDERGOING ART: A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL

POLAK DE FRIED E.; BOSSI NM; NOTRICA JA; VAZQUEZ MH

Boston

Congreso; 69th ASRM Annual Meeting held Conjoint with IFFS; 2013

American Society of Reproductive Medicine

Title: VITAMIN-D TREATMENT DOES NOT IMPROVE PREGNANCY RATES IN PATIENTS UNDERGOING ART: A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL. Ester Polak de Fried1, Nancy M Bossi1, Judith A Notrica1 and Monica H Vazquez Levin1,2. 1Reproductive Medicine, CER Medical Institute - Affiliated to the School of Medicine - Buenos Aires University, Humboldt 2263 C.A.B.A., Buenos Aires, Argentina, 1425 and 2Reproductive Medicine, IBYME Institute of Biology and Experimental Medicine, Vuelta de Obligado 2490 C.A.B.A., Buenos Aires, Argentina, 1428. Objective: To evaluate the effect of Vitamin-D (VD) to improve pregnancy rates in ART. Recent evidence shows that low VD is associated with infertility and low pregnancy rates in IVF. Design: Prospective, randomized, double-blind placebo-controlled trial. Materials and Methods: Fifty two patients were computer randomized during 5 consecutive months into Group A = at least one monthly oral VD dose (100.000 IU) and Group B = placebo. Basal and post treatment VD was evaluated. VD ranges (ng/ml): deficiency (30). ICSI cycles: 34 (A=17, B=17) and oocyte donation (OD)/ICSI cycles: 18 (A=9, B=9) were evaluated. Statistics: Man-Withney rank-sum test and Fisher exact test. P