141) Effect of D-Phenylalanine on anxiety in the plus maze test in rats.

GUEVARA, M.A. ; GIAI, M.; LANDA, A.I.; GARGIULO, A.P.I.; MESONES, H.L. ; GARGIULO, P.A.

Mendoza.-

Congreso; XXXIV Reunión Científica Anual de la Sociedad de Biología de Cuyo.; 2016

Sociedad de Biología de Cuyo.-

141) EFFECT OF D-PHENYL-ALANINE ON ANXIETY IN THE PLUS MAZE TEST INRATS.Guevara MA*, Giai M*, Landa*,Gargiulo API*, Mesones HL*?, Gargiulo PA*?.* Laboratory of Neurosciences and Experimental Psychology. Area of Pharmacology. Faculty of Medical Sciences. National University of Cuyo. (CONICET). ? Argentine Association of Psychiatrists (AAP). E-mail: vetguevara@hotmail.comD-Phenyl-Alanine (DPA) has a recognized antidepressant action, and it has been shown in several clinical studies. Some patients refer a mild anxiogenic effect receiving it. Due to this reason we studied in the present experiment the possible anxiogenic effect of this drug. Male rats weighing 280-300 g from a Holtzman derived colony were used, divided in four groups. These rats were injected with saline or DPA (7.5, 15 and 30 mg/kg) 3 min. before testing. The test was the Plus-Maze test, in the conditions of our laboratory, with the classical parameters. Clear results were obtained with all doses. Time spent in the open arm was significantly decreased by all doses (p