145) Synergistic effect of ketamine and fluoxetine in the forced swimming test.

MÁRQUEZ HERRERO, S. ; HERNÁNDEZ, J.I. ; GARGIULO, P.A. ; GUEVARA, M.

Mendoza.-

Congreso; XXXIV Reunión Científica Anual de la Sociedad de Biología de Cuyo.; 2016

Sociedad de Biología de Cuyo.-

145) SYNERGISTIC EFFECT OF KETAMINE AND FLUOXETINE IN THE FORCED SWIMMING TESTMarquezHerrero S, Hernandez JI, Gargiulo PA, Guevara M. Laboratory of Neurosciences and Experimental Psychology. Area of Pharmacology. Faculty of Medical Sciences. National University of Cuyo. (CONICET). E-mail:santiagomarquezherrero@gmail.comMajor depression is a prevalent psychiatric disorder. Different pharmacological treatments have their limitations as regards their efficacy and time of latency, requiring even weeks before showing clinical effects. Recent research hasshown that NMDA (N-Methyl-D-Aspartate) receptors might be involved in Major depression?s pathophysiology and therefore they are possible therapeutic targets. The present study investigates the possible synergistic interaction between NMDA antagonist Ketamine and SSRI (selective serotonin reuptake inhibitor) Fluoxetine. Holtzmann derived rats where treated with ketamine (2.5, 5 and 10 mg/kg) and fluoxetine (5, 10 and 20 mg/kg) 30 minutes before subjected to the forced swimming test. Higher doses of Fluoxetine (20 mg/kg, p