142) Inhibitory effect of long term memory induced by subanesthetic doses of ketamine on novel object recognition test in rats.

SANTIN, C. ; ROMANOWICZ, E. ; GARCIA MENENDEZ, S, ; GUEVARA, M.A, ; GARGIULO, P.A.

Mendoza.-

Congreso; XXXIV Reunión Científica Anual de la Sociedad de Biología de Cuyo.; 2016

Sociedad de Biología de Cuyo.-

142) INHIBITORY EFFECT ON LONG TERM MEMORY INDUCED BY SUBANESTHETIC DOSES OF KETAMINE ON NOVEL OBJECT RECOGNITION TEST IN RATSSantin C*, Romanowicz E*, Garcia Menendez S, Guevara MA, Gargiulo PA. Laboratory of Neurosciences and Experimental Psychology. Area of Pharmacology. Faculty of Medical Sciences. National University of Cuyo. (CONICET). E-mail: e_romanowicz2@hotmail.com*Equal contributionKetamine is a dissociative anesthetic. It was derived from phencyclidine, an abuse drug used since 1965.Pharmacologically, Ketamine is a noncompetitive NMDA glutamatergic receptor blocker. It binds intracanalicularly the phencyclidine site. Given its pharmacological action, it has been used to induce animal models of schizophrenia. Within these models novel object recognition test involves variables related to memory and perception. Both variables have been previously studied by us in different models. In this study the effect of Ketamine is experimented. Rats of a Holtzman derived colony weighing 240-290 g were used. It was realized an intraperitoneal administration of ketamine in subanestheticdoses (1.25, 2.5 and 5 mg / kg ip) 10 min before training. Test was realized 24 hours after training. The effects on novel object recognition test parameters was studied. We observed that the treatment produced a significant increase intotal scan time in the evaluation session at 2.5 (p