INVESTIGADORES
GARGIULO Pascual Angel
congresos y reuniones científicas
Título:
102) Effects of D-phenylalanine and classic antidepressants in an animal model of depressive disorder.
Autor/es:
MORENO ADARO, O.F.; SABINA; L., BERRÍOS, C.; GARCÍA MENÉNDEZ, S.; LANDA, A.I.; LAFUENTE SÁNCHEZ, J.V.; MESONES ARROYO, H.L.; GARGIULO, P.A.
Lugar:
Mendoza
Reunión:
Congreso; XXVI Reunión Anual de la Sociedad de Biología de Cuyo. Mendoza, 5 a 7 de Diciembre de 2008.-; 2008
Institución organizadora:
Sociedad de Biología de Cuyo. Mendoza, 5 a 7 de Diciembre de 2008.-
Resumen:
102) 2008. Moreno Adaro, O.F.; Sabina; L., Berríos, C.; García Menéndez, S.;  Landa, A.I.;  Lafuente Sánchez, J.V.; Mesones Arroyo, H.L.; Gargiulo, P.A. Effects of D-phenylalanine and classic antidepressants in an animal model of depressive disorder. XXVI Reunión Anual de la Sociedad de Biología de Cuyo. Mendoza, 5 a 7 de Diciembre de 2008.- Some evidences indicate the usefulness of D-aminoacids in the treatment of depressive disorder. They have been used in association with classical antidepressants. However, their effect has not been evaluated in an animal model of depressive disorder. The aim of this study has been to assess the effect of D-phenylalanine in the Porsolt forced swimming test, compared with imipramine and fluoxetine. Adult male rats (BW 240 to 290 g) of a Holtzman colony were divided into 4 treatment groups: control saline (n=9), imipramine (20 mg/kg, n=9), fluoxetine (10 mg/kg, n=10) and D-phenylalanine (30 mg/kg, n=10). Climbing behavior was increased by imipramine when compared with saline (p<0.05) and fluoxetine or D-phenylalanine (p<0.01 in both cases). Swimming behavior was significantly decreased by imipramine (p<0.01 vs fluoxetine), and clearly increased by D-phenylalanine (p<0.001 vs all other groups). We conclude that imipramine increased climbing behaviour, showing a typical noradrenergic profile and decreasing swimming behavior. Fluoxetine did not cause modifications at the dose used. D-phenylalanine induced a very significant increase in swimming behavior, showing a serotonergic profile at the dose used.