INVESTIGADORES
GARGIULO Pascual Angel
congresos y reuniones científicas
Título:
113) Is PPI cognitive? What have we learned from a correlative approach?
Autor/es:
YEE BK ; PELEG-RAIBSTEIN, D.; HAUSER, J. ; SINGER, P. ; DUBROQUA, S. ; BITANIHIRWE, B. ; LLANO LOPEZ, L. ; GARGIULO, P.A. ; FELDON, J.
Lugar:
Sardinia
Reunión:
Congreso; 2010 Annual Meeting of the International Behavioral Neuroscience Society.; 2010
Institución organizadora:
International Behavioral Neuroscience Society.
Resumen:
113) 2010. Yee, B.K.; Peleg-Raibstein, D.; Hauser, J.; Singer, P.; Dubroqua, S.; Bitanihirwe, B.; Llano Lopez, L.; Gargiulo, P.A.; Feldon, J. Is PPI cognitive? What have we learned from a correlative approach? International Behavioral Neuuroscience Society. June 8-13. 2010. IBNS June 2010.Is PPI cognitive? What have we learned from a correlative approach?Benjamin K. Yee 1, Daria Peleg-Raibstein 1, Jonas Hauser 1, Philipp Singer 1, Sylvain Dubroqua 1, Byron Bitanihirwe 1, Luis LLano Lopez 2, P.A. Gargiulo 2, Joram Feldon 1. 1 Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH-8603 Schwerzenbach, Switzerland. 2 Laboratorio de Neurociencias y Psicología Experimental, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina. Prepulse inhibition (PPI) is a common translational paradigm for evaluating sensorimotor gating, whereby a weak ?prepulse? stimulus impedes response to a succeeding ?pulse? stimulus. Typically a startle-eliciting acoustic pulse stimulus is employed, and PPI is defined as the diminution of the startle reaction when the pulse stimulus was shortly preceded by a weak prepulse stimulus. Possible links between PPI and other controlled attention systems as well as performance in other cognitive domains are of obvious interest but have remained ill-defined. Such links are informative on the psychological nature of PPI and its clinical value as a predictor of overt symptoms. Attempts have been made to identify possible associations between PPI impairment and specific cognitive deficits characteristic of different diseases or personality traits, as well as concomitant changes in cognitive functions induced by PPI-disruptive or -enhancing treatments. We have instead attempted to address this issue using a correlative approach in healthy unperturbed laboratory mice. Individual differences in PPI expression were compared to those observed in spatial learning and memory, visual vigilance, proneness to develop amphetamine sensitization, and brain content of specific neurochemicals. No evidence of a link between PPI expression and memory processes was revealed. Surprisingly, PPI predicts choice accuracy rather than speed of processing or response time in a serial reaction time test. This might suggest that PPIs contribute to increase signal-to-noise ratio, which is consistent with the neurochemical evaluation and the related outcome in amphetamine-induced behavioural sensitization.