122) Ketamine disrupts working memory in a Hole Board Task.

GUEVARA, M.A. ; JIMÉNEZ BAIGORRIA, L. ; TINNIRELLO, B.; RODRÍGUEZ, J. ; SERRANO, L. ; LANDA, A.I. ; BAIARDI, G. ; GARGIULO, P.A.

San Juan.

Encuentro; Second Joint Meeting of the Biology Societies from Argentina (Segunda Reunión Conjunta de Sociedades de Biología de la República Argentina).; 2011

Sociedad de Biología de Cuyo.

NQ18 - KETAMINE DISRUPTS WORKING MEMORY IN A HOLE BOARD TASK Guevara M1, Jiménez Baigorria L1, Tinnirello B1, Rodríguez J1, Serrano L1, Landa, AI1, Baiardi G2, Gargiulo PA1. 1Laboratory of Neurosciences and Experimental Psychology, FCM, UNCuyo, Mendoza Argentina. 2Laboratory of Neuro-pharmacology, FCQ, UCC, Córdoba, Argentina. Ketamine, a N-methyl-D-Aspartic-acid (NMDA) receptor antagonist, is an anesthetic that has psychotogenic effects in special conditions. Since working memory deficits have been described in schizophrenia, we studied here the effects of Ketamine on this function, using a hole board test to search for a disruption in this task. Male rats derived from a Holtzman colony were used weighing 240-270 g, divided in 5 groups (saline control, Ketamine 5, 10, 15 and 20 mg/kg, n=19-24). Locomotor activity (ambulatory, non ambulatory and vertical movements) and number of entrances to the holes were measured. A significant modification on locomotiona and holes exploration parameters was observed in the test. We conclude that Ketamine disrupts working memory within present conditions.