120) Potential implications of Ki-67 expresion in surgically resected pituitary adenomas.

SERRANO, L. SERENO C, CONDOMÍ ALCORTA S, KATZ D, SELVLEVER G, GARGIULO PA, CERVIO A.

San Juan.

Encuentro; Second Joint Meeting of the Biology Societies from Argentina (Segunda Reunión Conjunta de Sociedades de Biología de la República Argentina).; 2011

Sociedad de Biología de Cuyo.

NQ3 - POTENTIAL IMPLICATIONS OF Ki-67 EXPRESSION IN SURGICALLY RESECTED PITUITARY ADENOMAS Serrano L1, Sereno C2, Condomí Alcorta S2, Katz D2, Selvlever G2, Gargiulo PA1, Cervio A2. 1Laboratory of Neurosciences and Experimental Psychology, FCM, UNCuyo, Mendoza, Argentina. 2Neurosurgery Department, FLENI, Buenos Aires, Argentina. Pituitary adenomas constitute the most frequent sellar neoplasms and account for about 15% of intracranial tumors. In spite of being benign, these tumors can grow sufficiently to compromise main encephalic and vascular structures within the skull base. In this work we characterized Ki67 activity in resected adenomas with respect to clinical and histopathological features. Though the quantification of this proliferation marker we aimed to assess the existence of factors which could be associated with a higher or lower proliferative rate. After revising a number of 79 cases we observed that the overall mean expression of Ki-67 was 2.30.22%. Our analysis did not demonstrate any difference in Ki-67 activity between sex, age or histopathological subtype. Nevertheless, there was a significantly higher Ki-67 expression in tumors which recurred F(1,77)=7,483;p