INVESTIGADORES
GARGIULO Pascual Angel
congresos y reuniones científicas
Título:
Anxiolytic effect induced by injection of chlorazepate dipotassium within the amygdala of male rats in the plus maze test.
Autor/es:
LLANO L, CAIF F, FRAILE M, LANDA AI, GARGIULO PA.
Lugar:
San LUis, Argentina.-
Reunión:
Congreso; XXIV Reunión Anual de la Sociedad de Biología de Cuyo. San Luis, 30/11 a 03/12 de 2006. Abstract en prensa en Biocell.; 2006
Institución organizadora:
Sociedad de Biología de Cuyo.-
Resumen:
Anxiolytic effect induced by injection of chlorazepate dipotassium within the amygdala of male rats in the plus maze test. LLANO L, Caif F, Fraile M, Landa AI, Gargiulo PA. Lab. Neuroc. Ps. Exp. (IMBECU-CONICET). A. Farm. D. Patol. F.C.M. U.N.C.-      The amygdala (Amy) , like medial pre-frontal cortex (mPFC) and ventral hippocampus (Hip), projects to the Nucleus Accumbens Septi (Acc) through glutamatergic pathways. The Amy is a structure that have been implicated in anxiety. Glutamatergic transmission within Acc modulates these effects. We studied here behavioral changes induced in the plus maze by the injection of chlorazepate dipotassium within origin nucleus of Acc afferences, Amy in this case. Rats bilaterally implanted by stereotaxic surgery were injected with saline (1 ìl each side, n=15-18), or chlorazepate dipotassium (1 or 2 ìg in 1 ìl, n=15-18). The drug injection induced an increase in time spent in the open arm (p<0.01, 2 ìg), open arm entries and open/closed arm quotient (p<0.05, 2 ìg), and extreme arrivals (p<0.05 for both doses). We conclude that GABAergic blockade within Amy induced an anxiolytic-like effect, with several characteristic behavioural patterns. Present study was supported with a grant of the Secretary of Science and Technology of the National University of Cuyo (06/J164).