Metabolic Association between Gut-Brain Axis in Autism Spectrum Disorders. Delgado, A.; Fochesato, A.; Juncos, L.; Gargiulo, P.A. En: Psychiatry and Neurosciences. Translational Approaches. Gargiulo, P.A. and Mesones, H.L. (Editors). Springer New York.

DELGADO, MARÍA ANDREA; FOCHESATO, ADRIANA; JUNCOS, LUIS ISAÍAS; GARGIULO, PASCUAL ANGEL

Psychiatry and Neurosciences. Translational Approaches. Gargiulo, P.A. and Mesones, H.L. (Editors). Springer New York. New York 2016. (ISBN: 978-3-319-53125-0).-

Springer

Lugar: New York / Zurich; Año: 2017; p. 465 - 476

Metabolic Association between Gut-Brain Axis in Autism Spectrum Disorders. Delgado, A.; Fochesato, A.; Juncos, L.; Gargiulo, P.A. En: Psychiatry and Neurosciences. Translational Approaches. Gargiulo, P.A. and Mesones, H.L. (Editors). Springer New York. New York 2017. (ISBN: 978-3-319-53125-0).-Abstract Autism Spectrum Disorder (ASD) is a severe, complex neurodevelopmental disorder, characterized by impairments in social interaction and communication with restricted and stereotyped behavior patterns. ASD symptoms result from a complex interaction between genetic and environment factors. Food intolerances, allergies, altered intestinal permeability (leaky gut), immune dysregulation, neuroinflammation and oxidative stress may trigger ASD symptoms. ASD patients have shown increased urinary levels of β-casomorphin and gliadorphin peptides produced by incomplete digestion of gluten proteins and milk casein. ?Leaky gut? may facilitate the transport of these peptides into the central nervous system (CNS) inducing direct ?opioid activity? affecting thus neurotransmission. ASD patients on gluten and/or casein-free diet have shown improvement in most of the behavior and cognitive scores. Immune dysregulation leads to a neuroinflammatory response that correlates between immune dysfunction with behavioral and cognitive impairments in ASD patients. Genetic variants of MET gene (7q31.2) are risk factors for ASD. MET receptor participates in brain cortex and cerebellum development and in gastrointestinal and immunological functions. A high percentage of ASD children have shown non-celiac gluten sensitivity, an immune reaction against gluten in subjects not affected with celiac disease with prominent mucosal eosinophil infiltration and increased blood eosinophilia. ASD patients have shown alterations in brain anatomy involved in language and social interaction skills, correlating with specific aspects of ASD symptoms. ASD behavior results from abnormal interactions between the opioid system and various pathways together with anatomical alterations in the CNS. Individualized diagnosis and prognostic predictions should provide effective personalized therapies in ASD patients.Key Words: Autism Spectrum Disorders, opioid peptides, Leaky gut, genetics, immune dysregulation.