INVESTIGADORES
GARGIULO Pascual Angel
artículos
Título:
Effects of NMDA and non-NMDA blockade in the nucleus accumbens on the plus maze test..-
Autor/es:
MARTÍNEZ, G.; ROPERO, C.; FUNES, A.; FLORES, E.; BLOTTA, C.; LANDA, A.I.; GARGIULO, P.A.
Revista:
PHYSIOLOGY AND BEHAVIOR
Editorial:
Elsevier Science Inc.
Referencias:
Año: 2002 p. 219 - 219
ISSN:
0031-9384
Resumen:
Abstract Effect of blocking N-methyl-D-aspartic acid (NMDA) and non-NMDA-glutamatergic receptors on performance in the plus-maze was studied in male rats bilaterally cannulated into the nucleus accumbens (Acc). Rats were divided into seven groups that received either 1 ml injections of saline, ( ± )2-amino-7-phosphonoheptanoic acid (AP-7, 0.2, 0.5, or 1 mg) or 2,3 dioxo-6-nitro-1,2,3,4,tetrahydrobenzo- ( f )quinoxaline-7-sulphonamide disodium (NBQX, 0.2, 0.5, or 1 mg) 15 min before testing. Time spent in open arm, time per entry, end arrivals, open, closed, and total arm entries, relationship between open-, closed-, and total arm entries, rearing, face-, head-, and body grooming, and number of fecal boli were recorded. Time spent in the open arm increased under AP-7 (0.5 and 1 mg; P < .01) and NBQX (1 mg; P < .05) treatment, whereas time per entry was increased only with AP-7 (1 mg; P < .05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 mg; P < .01) and NBQX (0.5 mg; P < .05); end arrivals were increased by the intermediate dose of AP-7 (0.5 mg/1 ml, P < .05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect. D 2002 Elsevier Science Inc. All rights reserved.N-methyl-D-aspartic acid (NMDA) and non-NMDA-glutamatergic receptors on performance in the plus-maze was studied in male rats bilaterally cannulated into the nucleus accumbens (Acc). Rats were divided into seven groups that received either 1 ml injections of saline, ( ± )2-amino-7-phosphonoheptanoic acid (AP-7, 0.2, 0.5, or 1 mg) or 2,3 dioxo-6-nitro-1,2,3,4,tetrahydrobenzo- ( f )quinoxaline-7-sulphonamide disodium (NBQX, 0.2, 0.5, or 1 mg) 15 min before testing. Time spent in open arm, time per entry, end arrivals, open, closed, and total arm entries, relationship between open-, closed-, and total arm entries, rearing, face-, head-, and body grooming, and number of fecal boli were recorded. Time spent in the open arm increased under AP-7 (0.5 and 1 mg; P < .01) and NBQX (1 mg; P < .05) treatment, whereas time per entry was increased only with AP-7 (1 mg; P < .05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 mg; P < .01) and NBQX (0.5 mg; P < .05); end arrivals were increased by the intermediate dose of AP-7 (0.5 mg/1 ml, P < .05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect. D 2002 Elsevier Science Inc. All rights reserved.ml injections of saline, ( ± )2-amino-7-phosphonoheptanoic acid (AP-7, 0.2, 0.5, or 1 mg) or 2,3 dioxo-6-nitro-1,2,3,4,tetrahydrobenzo- ( f )quinoxaline-7-sulphonamide disodium (NBQX, 0.2, 0.5, or 1 mg) 15 min before testing. Time spent in open arm, time per entry, end arrivals, open, closed, and total arm entries, relationship between open-, closed-, and total arm entries, rearing, face-, head-, and body grooming, and number of fecal boli were recorded. Time spent in the open arm increased under AP-7 (0.5 and 1 mg; P < .01) and NBQX (1 mg; P < .05) treatment, whereas time per entry was increased only with AP-7 (1 mg; P < .05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 mg; P < .01) and NBQX (0.5 mg; P < .05); end arrivals were increased by the intermediate dose of AP-7 (0.5 mg/1 ml, P < .05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect. D 2002 Elsevier Science Inc. All rights reserved.mg) or 2,3 dioxo-6-nitro-1,2,3,4,tetrahydrobenzo- ( f )quinoxaline-7-sulphonamide disodium (NBQX, 0.2, 0.5, or 1 mg) 15 min before testing. Time spent in open arm, time per entry, end arrivals, open, closed, and total arm entries, relationship between open-, closed-, and total arm entries, rearing, face-, head-, and body grooming, and number of fecal boli were recorded. Time spent in the open arm increased under AP-7 (0.5 and 1 mg; P < .01) and NBQX (1 mg; P < .05) treatment, whereas time per entry was increased only with AP-7 (1 mg; P < .05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 mg; P < .01) and NBQX (0.5 mg; P < .05); end arrivals were increased by the intermediate dose of AP-7 (0.5 mg/1 ml, P < .05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect. D 2002 Elsevier Science Inc. All rights reserved.f )quinoxaline-7-sulphonamide disodium (NBQX, 0.2, 0.5, or 1 mg) 15 min before testing. Time spent in open arm, time per entry, end arrivals, open, closed, and total arm entries, relationship between open-, closed-, and total arm entries, rearing, face-, head-, and body grooming, and number of fecal boli were recorded. Time spent in the open arm increased under AP-7 (0.5 and 1 mg; P < .01) and NBQX (1 mg; P < .05) treatment, whereas time per entry was increased only with AP-7 (1 mg; P < .05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 mg; P < .01) and NBQX (0.5 mg; P < .05); end arrivals were increased by the intermediate dose of AP-7 (0.5 mg/1 ml, P < .05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect. D 2002 Elsevier Science Inc. All rights reserved.mg; P < .01) and NBQX (1 mg; P < .05) treatment, whereas time per entry was increased only with AP-7 (1 mg; P < .05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 mg; P < .01) and NBQX (0.5 mg; P < .05); end arrivals were increased by the intermediate dose of AP-7 (0.5 mg/1 ml, P < .05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect. D 2002 Elsevier Science Inc. All rights reserved.mg; P < .05) treatment, whereas time per entry was increased only with AP-7 (1 mg; P < .05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 mg; P < .01) and NBQX (0.5 mg; P < .05); end arrivals were increased by the intermediate dose of AP-7 (0.5 mg/1 ml, P < .05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect. D 2002 Elsevier Science Inc. All rights reserved.mg; P < .01) and NBQX (0.5 mg; P < .05); end arrivals were increased by the intermediate dose of AP-7 (0.5 mg/1 ml, P < .05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect. D 2002 Elsevier Science Inc. All rights reserved.mg/1 ml, P < .05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect. D 2002 Elsevier Science Inc. All rights reserved.D 2002 Elsevier Science Inc. All rights reserved. Keywords: NMDA-glutamatergic transmission; Nucleus accumbens; Anxiety; Plus-maze; Schizophrenia; Affective flatness; PerceptionNMDA-glutamatergic transmission; Nucleus accumbens; Anxiety; Plus-maze; Schizophrenia; Affective flatness; Perception