INVESTIGADORES
GARGIULO Pascual Angel
artículos
Título:
Anxiolytic effect of allopregnanolone is associated with changes in gonadal hormonal status in female rats. -
Autor/es:
LACONI, M.R.; CASTELLER, G.; GARGIULO, P.A.; BREGONZIO, C.; CABRERA, R.J.
Revista:
EUROPEAN JOURNAL OF PHARMACOLOGY
Editorial:
Elsevier Science
Referencias:
Año: 2001 p. 111 - 111
ISSN:
0014-2999
Resumen:
Abstract The behavioural display in the plus-maze, an established experimental model of anxiety, was studied in rats injected into the lateral Ž . Ž . brain ventricle i.c.v. with the neurosteroid 3a-hydroxy-5a-pregnan-20-one allopregnanolone . Female rats under different gonadal hormonal status were chosen. Allopregnanolone enhanced exploration of the open arms in both estrous rats and ovariectomized estrogen and progesterone primed rats. No effect was observed in diestrous 1 and ovariectomized not-primed rats. In all cases, the plus-mazebrain ventricle i.c.v. with the neurosteroid 3a-hydroxy-5a-pregnan-20-one allopregnanolone . Female rats under different gonadal hormonal status were chosen. Allopregnanolone enhanced exploration of the open arms in both estrous rats and ovariectomized estrogen and progesterone primed rats. No effect was observed in diestrous 1 and ovariectomized not-primed rats. In all cases, the plus-maze Ž . locomotor-exploratory behaviour was not affected by allopregnanolone. The GABA receptor antagonist, bicuculline 9.8 mM i.c.v. Alocomotor-exploratory behaviour was not affected by allopregnanolone. The GABA receptor antagonist, bicuculline 9.8 mM i.c.v. A reversed the allopregnanolone action in the ovariectomized primed rats. When bicuculline was injected i.c.v. in conjunction with Ž . allopregnanolone, the anxiogenic effect of bicuculline was reversed by the highest dose 25 mM of allopregnanolone only. These results suggest that allopregnanolone exerts an anxiolytic action interacting with the GABA receptor in an estrogen-dependent manner. q2001 Aallopregnanolone, the anxiogenic effect of bicuculline was reversed by the highest dose 25 mM of allopregnanolone only. These results suggest that allopregnanolone exerts an anxiolytic action interacting with the GABA receptor in an estrogen-dependent manner. q2001 Aq2001 A Elsevier Science B.V. All rights reserved. Keywords: Anxiety; Neurosteroid; Allopregnanolone; GABA receptor; Estrous cycle AAnxiety; Neurosteroid; Allopregnanolone; GABA receptor; Estrous cycle A
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