INVESTIGADORES
GARGIULO Pascual Angel
artículos
Título:
Visual discrimination in pigeons impaired by glutamatergic blockade of nucleus accumbens.
Autor/es:
GARGIULO, P.A.; SIEMANN, M.; DELIUS, J.
Revista:
PHYSIOLOGY AND BEHAVIOR
Editorial:
Elsevier Science Inc.
Referencias:
Año: 1998 p. 705 - 709
ISSN:
0031-9384
Resumen:
GARGIULO, P. A., M. SIEMANN AND J. D. DELIUS. Visual discrimination in pigeons impaired by glutamatergic blockade of
nucleus accumbens. PHYSIOL. BEHAV. 63(4) 705709, 1998.The nucleus accumbens septi (Acc) is thought to be involved in the
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
nucleus accumbens. PHYSIOL. BEHAV. 63(4) 705709, 1998.The nucleus accumbens septi (Acc) is thought to be involved in the
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
nucleus accumbens. PHYSIOL. BEHAV. 63(4) 705709, 1998.The nucleus accumbens septi (Acc) is thought to be involved in the
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
Visual discrimination in pigeons impaired by glutamatergic blockade of
nucleus accumbens. PHYSIOL. BEHAV. 63(4) 705709, 1998.The nucleus accumbens septi (Acc) is thought to be involved in the
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.
PHYSIOL. BEHAV. 63(4) 705709, 1998.The nucleus accumbens septi (Acc) is thought to be involved in the
control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions
are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would
be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc
on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were
examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and
dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and
apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic
acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of
pigeons. © 1998 Elsevier Science Inc.