PRENATAL STRESS INDUCES METABOLIC DISORDERS IN BALB/C MICE

JUAREZ YR; CALVO JC; GENARO AM; BURGUEÑO AL

Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS. LXII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC).; 2017

Sociedad Argentina de Investigación Clínica (SAIC)

Prenatal exposure to maternal stress may program the fetal HPA axis, potentially leading to altered metabolism in later life, associated with obesity and diabetes. This effects could be worsen in adulthood if theindividual doesn?t eat healthy. In the present work, we studied the effect ofprenatal stress (PS) on metabolism and the impact of high fat diet (HFD). Forthis purpose pregnant BALB/c female mice were stressed by movement restrictionduring the last week of pregnancy leaving a control group (NPS). Afterweaning, mice were fed with HFD or a standard diet (SD). After 8 weeks of diet, PS+HFD females showed a higher body weight (BW) than the other groups (p