Tumor effect on its adipose microenvironment in human breast cancer ? an immunohistochemical analysis

FLETCHER, SABRINA JOHANNA; SACCA, PAULA ALEJANDRA; CROSBIE ML; URSINO A; SANTISO N; FRASCAROLLI MC; GUTIÉRREZ A; AMATO AR; DREZSMAN R; CARÓN RW; CALVO JUAN CARLOS; PISTONE CREYDT VIRGINIA

Mendoza

Congreso; XXXIV Reunión Científica Anual de la Sociedad de Biología de Cuyo.; 2016

Sociedad de Biología de Cuyo

Tumor stroma is one of the emerging topics of interest in cancer research. In breast cancer, tumor epithelial cells interactdynamically with different stromal cells. This interaction has been shown to be crucial for tumor progression and dissemination.Adipose tissue is the main component of the breast stroma. Therefore, in this study we aim to identify the effect that breast tumorshave on their adipose microenvironment. For this we collected samples of human breast adipose tissue from tumor breasts (hATT)of patients with cancer and from normal breasts (hATN) of healthy women. The explants were fixed with formaldehyde 4%,embedded in paraffin and sliced for immunohistochemical analysis. We found that adiponectin (one of the major adipokines andwith anti-tumorigenic effects) expression was significantly increased in hATN vs hATT (p