Lupane Triterpenoids and New Derivatives as Antiproliferative Agents Against Prostate Cancer Cells

CASTRO MJ; CAREAGA VP; SACCA PA; FARAONI MB; MURRAY AP; CALVO JC

ANTICANCER RESEARCH

INT INST ANTICANCER RESEARCH

Año: 2019 vol. 39 p. 3835 - 3845

0250-7005

Abstract. Background/Aim: This study examined the potential role of natural triterpenoids lupeol, calenduladiol and heliantriol B2, and a set of 19 derivatives, as antiproliferative and antimetastatic agents against prostatecancer cells. Materials and Methods: Natural triterpenoids were isolated from Chuqiraga erinaceae. Analogs were obtained by transformations of lupeol and calenduladiol. The effects of compounds on PC-3 and LNCaP cells weredetermined using MTT assay. Compounds with half-maximal inhibitory concentration