Statement of Changes in Muscle Mass during Life by DXA

DI GERGORIO S; MALOUF J; DEL RIO L; OLIVERI B

Congreso; Meeting America Society for Bone and Mineral Research; 2014

Aging is a physiological process that involves a progressive, generalized impairment of the functions of various agencies and systems. Muscle mass decreases especially in the lower extremities, impairment in gait speed, stability and an increased fall. So the clinical relevance of sarcopenia is widely recognized, but currently there is no universally accepted definition of the disorder. If muscle mass as part of the diagnostic definition of sarcopenia, the measuring it needs to be feasible for both research and in clinical practice, and feasible in older people. The study of Whole body composition by DXA permit quantify lean mass and calculate as the appendicular fat-free mass of the upper and lower limbs divided by body height squared, a patient?s muscle mass index indicated sarcopenia if it was >2 standard deviations (SD) below the sex-specific average in healthy young men or women . There is a demographic variation due to physical and diet habitus in body composition. Objective: Evaluate the lean mass by DXA in healthy young people, to obtain de normative values to estimate in our old population the degrade of lost lean mass that allow us to discriminate against the elderly at risk. Population and Methods: A retrospective longitudinal. Subjects of both sexes stratified by decades of age were measured with Hologic (965 subjects) ; iDXA (930subjects) and Prodigy (1110).The population was stratified by sex and decade of age , 20th-40th were used as reference category . Total Lean Mass (TLM); Legs Lean Mass (LLM); Appendicular Lean Skeletal Mass and its respective index related to (height ?m-)2 , Appendicular Lean Skeletal Mass Index (ALSMI)and Lean mass index- LMI. T test was applied to establish statistical significance of media differences between the measures obtained and compared with the reference decade, p