INVESTIGADORES
OLIVERI Maria Beatriz
congresos y reuniones científicas
Título:
Effect of supplementation with different doses of vitamin D3 and D2 on 25 Hydroxyvitamin D levels
Autor/es:
SEIJO M; MASTAGLIA SR; SOMOZA J; BAGUR A; OLIVERI B
Lugar:
Buenos Aires
Reunión:
Congreso; XXV Reunion Anual AAOMM; 2008
Institución organizadora:
AAOMM
Resumen:
Optimum vitamin D2 (D2) and D3 (D3) supplementation regimen to achieve adequate 25 hydroxyvitamin D (25OHD) levels are controversial. The present work sought to assess the efficacy of daily doses of D2 and intermittent doses of D3 on 25OHD levels and bone mineral metabolism (BMM) in healthy postmenopausal women (PMW). Forty PMW, age (X±DS) 65.4±5 years were divided into 5 groups (G) and studied during 3 months. G1, G2 and G3 received a daily D2 dose of 800, 4.800, and 9.600IU respectively; G4 received a single 100.000IU dose of D3; G5 received 100.000IU of D3 at baseline and at 45 days. Condition or medication affecting BMM; vitamin D supplementation were excluded. Serum calcium, phosphorus, 25OHD, bone alkaline phosphatase, Cross Laps and intact parathormone (iPTH), and 24 hour urine calcium and creatinine were determined. At 3 months, 25OHD levels had increased significantly in all groups, reaching average concentrations above 30 ng/ml in G2 and G3 (Table 1) 25OHD (ng/ml) Baseline 3 Months % change G1 n 6 13.9±4.8 22.2±2.8⁎ 59.7 G2 n 6 12.8±5.0 31.6±12.7⁎ 146.9 G3 n 8 12.0±5.6 38.1±11.6⁎# 217.5 G4 n 11 12.2±4.2 22.9±3.7⁎° 87.7 G5 n 9 13.3±4.2 27.3±5.6⁎° 105.3 ⁎Per Group: p<0.05 #G1vsG3: p<0.002 °G3 vs G4 and G5: P<0.02 The remaining biochemical variables remained within normal range. Although the studied parameters showed no significant change, iPTH tended to decrease with daily D2 (G1:-38%; G2:-24%; G3:-30%; G4:-2%; G5:-3%). Conclusions: Optimum 25OHD levels are effectively attained with high daily doses of D2. A 100.000IU dose of D3 (1 or 2 in 3 months) is not sufficient to attain adequate 25OHD levels; higher doses or frequency may be required. doi:10.1016/j.bone.2008.10.011
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