INVESTIGADORES
OLIVERI Maria Beatriz
congresos y reuniones científicas
Título:
Bone density and geometry in women with osteopenia,osteoporosis and hip fractures
Autor/es:
BAGUR A; SEIJO M; SOLIS F; MAUTALEN C; OLIVERI B
Lugar:
Nashville,USA
Reunión:
Congreso; 27th Meeting American Society Bone and Mineral Research; 2005
Institución organizadora:
American Society Bone and Mineral Research
Resumen:
Bone Density and Geometry in Women With Osteopenia, Osteoporosis and Hip FracturesA. Bagur, M. Seijo*, F. Solis*, C. Mautalen*, B. Oliveri*. Sección Osteopatías Médicas, Hospital de Clínicas, Universidad de Buenos Aires, Buenos Aires, Argentina.Presentation Number: M073Bone mineral density (BMD) and femur geometry are predictors of osteoporotic hip fractures (HF) (Osteoporos Int 5:167,1995). The aim of this study was to evaluate BMD and femur geometry of control women (C), patients with osteopenia (O), osteoporosis (OP) and HF. The study population comprised 75 C (age: 69.8 ± 5.2 years), 132 O (age: 70 ± 6.3 years), 48 OP (age 74.1 ± 6.3 years) and 13 with recent FC (age: 75.2 ± 8.8 years); BMD of the hip contralateral to HF was determined in the latter. BMD and femoral geometry were evaluated by DXA (Lunar Prodigy). BMD of femoral neck (FN), Ward triangle (W), trochanter (T), total femur (TF), upper FN (UFN) and lower FN (LFN) was determined. As regards geometry, hip axis length (HAL), cross sectional moment of inertia (CSMI), and cross sectional areas (CSA) of the femoral neck were evaluated. The following results were obtained (X ± 1SD): Controls Osteopenia Osteoporosis Hip Fractures Height 153.4 ± 0.06 152.9 ± 0.06 151.6 ± 0.06 156.1 ± 0.1*** Weight 71 ± 11.0 67.2 ± 10.1* 59.8 ± 10.1**** 61 ± 11.15**** BMD FN 0.988 ± 0.09 0.771 ± 0.05**** 0.642 ± 0.031**** 0.688 ± 0.11**** BMD UFN 0.814 ± 0.11 0.614 ± 0.06**** 0.497 ± 0.042**** 0.507 ± 0.06**** BMD LFN 1.153 ± 0.10 0.924 ± 0.07**** 0.781± 0.05**** 0.865 ± 0.2**** BMD T 0.858 ± 0.09 0.687 ± 0.09**** 0.669 ± 0.06**** 0.55 ± 0.13**** BMD TF 1.046 ± 0.09 0.831 ± 0.09**** 0.669 ± 0.06**** 0.693 ± 0.14**** HAL 102.9 ± 6.15 102.07 ± 5.62 103.6 ± 4.92 110.2 ± 7.01*** p<0.01 ;***p<0.001; ****p<0.0001 versus control groupA greatest decrease ranging from 25 to 39% was observed in the upper femoral neck region. OP women presented decreased Height (151 ± 0.06 vs 156 ± 0.10 m, p<0.05) and HAL (103.6 ± 4.9 vs 110.2 ± 7.0 mm, p< 0.003) compared with HF.Our results show that: 1- Femur BMD decreased progressively in patients with O, OP and HF, compared with C. 2- The decrease was greatest at the level of the upper femoral neck, which is where the fracture may start. 3- Hip geometry allowed differentiating the fractured population from the osteoporotic population. 4- An index combining BMD and geometry may prove to be a useful predictor of hip fracture.
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