Effectiveness of a single 100000 IU dose of vitamin D3 in hypovitaminosis D patients

FERROV; BAGUR A; GONZALEZ D; FERNANDEZ MC; SEIJO M; OLIVERI B; PARISI MS

BsAs

Congreso; XXV Reunion Anual AAOMM; 2008

AAOMM

Effectiveness of a single 100.000IU dose of vitamin D3 in hypovitaminosis D patients V. Ferro, A. Bagur, D. Gonz¨¢lez, M.C. Fern¨¢ndez, M. Seijo, B. Oliveri, M.S. Parisi Secci¨®n Osteopat¨ªas M¨¦dicas, Hospital de Cl¨ªnicas, Universidad de Buenos Aires; Centro de Osteopat¨ªas M¨¦dicas, Buenos Aires, Argentina There is no consensus on the adequate dose/scheme to rapidly achieve desirable 25hydroxivitamin D (25OHD) levels. This study sought to evaluate the effectiveness of a single 100.000IU dose of vitamin D3 in attaining desirable 25OHD levels in hypovitaminosis D patients. We analyzed 38 clinical records of women with 25OHD levels <32 ng/ml. Results of serum calcium, phosphorus, bone alkaline phosphatase, crosslaps and intact parathormone (iPTH), and urine calcium were analyzed at baseline and at 90 days post-100.000IU/vitD3 administration. Age was 63.3¡À9.6years (X¡ÀDS). Patients were divided according to baseline 25OHD levels. G1: <=10 ng/ml (n=2), G2:>10 and<=20 ng/ml (n=19) and G3:>20 and <32 ng/ml (n=17). iPTH levels were increased in 8 patients. All remaining parameters were within normal ranges. At day 90, 21 (55%) patients had desirable 25OHD levels (>=32 ng/ml). 25OHD values increased an average 80% in the whole group, 20.3¡À5.9 vs 33.4¡À8.8 ng/ml (p<0.001), 193% in G1 (9.5¡À0.7 vs 27.5¡À6.4 ng/ml), 111% in G2 (16.5¡À3.1 vs 34.1¡À10.5 ng/ml, p<0.001), and 32% in G3 (25.7¡À2.5 vs 33.3¡À6.8 ng/ml, p<0.01). Increases correlated inversely with baseline 25OHD (r:-0.69, p<0.001). 50% of G1, 63% of G2, and 53% of G3 attained 25OHD levels ¡Ý32 ng/ml. High baseline iPTH levels remained elevated. There were no cases of hypercalcemia/hypercalciuria. 100.000IU of vit D3 were insufficient to obtain desirable 25OHD (>=32 ng/ml) levels in almost half the patients, and to normalize iPTH levels. Assessing 25OHD levels could be useful to determine the need for another dose. A vitD3 dose above 100.000IU or additional dose, are necessary when desirables levels are not reached. doi:10.1016/j.bone.2008.10.012