INVESTIGADORES
OLIVERI Maria Beatriz
artículos
Título:
VITAMIN D LEVELS AND THEIR IMPACT ON MINERAL METABOLISM IN HIV INFECTED PATIENTS: AN EXPLORATORY STUDY
Autor/es:
MASTAGLIA SR; WATSON DZ; BELLO NATALIA; FRIDMAN V; DR DANIEL STECHER; FRIDMAN V; STECHER D; OLIVERI B
Revista:
Clinical Cases in Mineral and Bone Metabolism
Editorial:
OrtoMed
Referencias:
Año: 2017
ISSN:
1724-8914
Resumen:
Vitamin D has immunomodulating properties. The nuclearreceptor for vitamin D is expressed in several immunecells, which convert 25-hydroxyvitamin D(25OHD)to the active form 1,25 hydroxyvitamin D (1,25(OH)2 D).Under conditions of infection, 1,25(OH)2 D promotes productionof cathelicidin (an antimicrobial peptide) inmonocytes and activated macrophages. In vitro studieshave shown the ability of cathelicidin to inhibit replicationof human immunodeficiency virus (HIV-1) in T CD4lymphocytes and macrophages. Objective. To evaluatevitamin D levels and their impact on mineral metabolismin HIV infected patients. Materials and methods. Seventy-four clinical records of HIV/AIDS patients seen at theoutpatients clinic were reviewed. The following datawere collected: age, sex, time since diagnosis of HIV,HIV-1 viral load, CD4 counts (absolute value and percentage),and mineral metabolism determinations:25OHD, intact parathormone (iPTH); serum calcium(sCa); serum phosphorus (sP) and serum crosslaps (sCTX).Vitamin D levels were stratified as follows: optimal:≥30ng/ml; insufficient: 21-29ng/ml; moderately deficient:20³ -25OHD- >10 ng/ml and severely deficient ≤10 ng/ml.Results. Fifty-five clinical records were included; 82% ofpatients had 25OHD levels below 30ng/ml (insufficient:23.6%, moderately deficient: 36.4%; and severely deficient:21.8%). A significantly higher serum PTH levels in the moderately and severely deficient groups than in theoptimal and insufficient groups was observed (p