INVESTIGADORES
KORNBLIHTT Alberto Rodolfo
artículos
Título:
Chromatin, DNA structure and alternative splicing
Autor/es:
NIETO MORENO, NICOLÁS; GIONO, LUCIANA; CAMBINDO BOTTO, ADRIÁN; MUÑOZ, MANUEL J.; KORNBLIHTT, ALBERTO R
Revista:
FEBS LETTERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 589 p. 3370 - 3370
ISSN:
0014-5793
Resumen:
Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time-window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing.
rds']