INVESTIGADORES
KORNBLIHTT Alberto Rodolfo
artículos
Título:
Coordination between transcription and pre-mRNA processing.
Autor/es:
CRAMER, P; SREBROW, A; KADENER S; WERBAJH SE; DE LA MATA M; MELEN, G; NOGUES G; KORNBLIHTT AR.
Revista:
FEBS LETTERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2001 p. 179 - 179
ISSN:
0014-5793
Resumen:
A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing.
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