Coordination between transcription and pre-mRNA processing.

CRAMER, P; SREBROW, A; KADENER S; WERBAJH SE; DE LA MATA M; MELEN, G; NOGUES G; KORNBLIHTT AR.

FEBS LETTERS

ELSEVIER SCIENCE BV

Año: 2001 p. 179 - 182

0014-5793

A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing.